Metabolic reprogramming of cancer cells within the tumor microenvironment typically occurs in response to increased nutritional, translation and proliferative demands. Altered lipid metabolism is a marker of tumor progression that is frequently observed in aggressive tumors with poor prognosis. Underlying these abnormal metabolic behaviors are posttranslational modifications (PTMs) of lipid metabolism-related enzymes and other factors that can impact their activity and/or subcellular localization. This review focuses on the roles of these PTMs and specifically on how they permit the re-wiring of cancer lipid metabolism, particularly within the context of the tumor microenvironment.
CITATION STYLE
Zhu, Y., Lin, X., Zhou, X., Prochownik, E. V., Wang, F., & Li, Y. (2022, December 1). Posttranslational control of lipogenesis in the tumor microenvironment. Journal of Hematology and Oncology. BioMed Central Ltd. https://doi.org/10.1186/s13045-022-01340-1
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