Abstract
Xerosis cutis is among the most frequent skin disorders associated with chronic renal failure, with an overall frequency of 75 % among renal dialysis patients. Several factors have been implicated in the development of uremic xerosis, including progressive shrinkage of eccrine sweat glands and atrophy of sebaceous glands. Xerosis predominantly affects extensor surfaces of forearms, legs, and thighs, and can present with pruritus although it has a distinct pathophysiology. Severe cases may exhibit scaling, desquamation, and fissures. A complete history, full skin exam, and thyroid exam are integral to the diagnosis of xerosis. Certain emollients and drugs are effectively used in the treatment of xerosis and result in significant improvements in quality of life.
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Wu, C. M., Wu, A. M., Lester, J., & Robinson-Bostom, L. (2015). Xerosis. In Dermatological Manifestations of Kidney Disease (pp. 75–79). Springer New York. https://doi.org/10.1007/978-1-4939-2395-3_6
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