Mcr-1 and blakpc-3 in escherichia coli sequence type 744 after meropenem and colistin therapy, Portugal

Abstract

Escherichia coli Ec36 was recovered from a patient in Portugal after treatment with meropenem and colistin. Besides an IncF plasmid with Tn1441d-blaKPC-3, already reported in clinical strains in this country, E. coli Ec36 co-harbored an IncX4::mcr-1 gene. Results highlight emerging co-resis-tance to carbapenems and polymyxins after therapy with drugs from both classes.