DJ-1 is a protein expressed in many tissues including the brain where it has been extensively studied due to its association with Parkinson’s Disease (PD). DJ-1 was reported to function as an antioxidant, redox-sensitive molecular chaperone, and transcription regulator, which protected cells from oxidative stress by modifying signaling pathways that regulate cell survival. Here we discuss our progress toward characterization of the DJ-1 function in the protection of RPE to oxidative stress.
CITATION STYLE
Bonilha, V. L., Rayborn, M. E., Yang, X., Xie, C., & Cai, H. (2014). Oxidative stress regulation by DJ-1 in the retinal pigment epithelium. Advances in Experimental Medicine and Biology, 801, 649–654. https://doi.org/10.1007/978-1-4614-3209-8_81
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