Neuroprotective strategies during cardiac surgery with cardiopulmonary bypass

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Abstract

Aortocoronary bypass or valve surgery usually require cardiac arrest using cardioplegic solutions. Although, in principle, in a number of cases beating heart surgery (so-called off-pump technique) is possible, aortic or valve surgery or correction of congenital heart diseases mostly require cardiopulmonary arrest. During this condition, the heart-lung machine also named cardiopulmonary bypass (CPB) has to take over the circulation. It is noteworthy that the invention of a machine bypassing the heart and lungs enabled complex cardiac operations, but possible negative effects of the CPB on other organs, especially the brain, cannot be neglected. Thus, neuroprotection during CPB is still a matter of great interest. In this review, we will describe the impact of CPB on the brain and focus on pharmacological and non-pharmacological strategies to protect the brain.

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Salameh, A., Dhein, S., Dähnert, I., & Klein, N. (2016, November 21). Neuroprotective strategies during cardiac surgery with cardiopulmonary bypass. International Journal of Molecular Sciences. MDPI AG. https://doi.org/10.3390/ijms17111945

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