Abstract
Manzamenones A-C (1-3) and E-F (5-6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against Tcell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 and 5 against TCPTP was 4 times more potent than that against protein tyrosine phosphatase-1B (PTP1B). © 2006 by MDPI.
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Wakuda, Y., Kubota, T., Shima, H., Okada, T., Mitsuhashi, S., Aoki, N., … Kobayashi, J. (2006). Manzamenones inhibit T-cell protein tyrosine phosphatase. Marine Drugs, 4(1), 9–14. https://doi.org/10.3390/md401009
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