Transcriptional regulation of ncx1 gene in the brain

Abstract

The ubiquitous sodium-calcium exchanger isoform 1 (NCX1) is a bidirectional transporter that plays a relevant role under physiological and pathophysiological conditions including brain ischemia by regulating intraneuronal Ca2+ and Na+ homeostasis. Although changes in ncx1 protein and transcript expression have been detected during stroke, its transcriptional regulation is still largely unexplored. Here, we reviewed our recent findings on several transcription factors including cAMP response element-binding protein (CREB), nuclear factor kappa B (NF-κB), and hypoxia-inducible factor-1 (HIF-1) in the control of the ncx1 gene expression in neuronal cells. © Springer Science+Business Media New York 2013.