Nanoparticle-aided radiotherapy for retinoblastoma and choroidal melanoma

Abstract

This work investigates the dosimetric feasibility of employing gold nanoparticles (AuNPs) or carboplatin nanoparticles (CNPs) to enhance radiotherapy (RT) treatment efficacy for ocular cancers: retinoblastoma (Rb) and choroidal melanoma (CM), during kV-energy internal and external beam radiotherapy. The results predict that substantial dose enhancement may be achieved by employing AuNPs or CNPs in conjunction with radiotherapy for ocular cancer using kVenergy photon beams. Brachytherapy sources yield higher dose enhancement than the external beam in kV energy range. However, the external beam has the advantage of being noninvasive.