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A sharp end to sugary wingless travels

Journal of Cell Biology
DOI: 10.1083/jcb.201408115
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Abstract

Drosophila melanogaster follicle stem cells are controlled by Wingless (Wg) ligands secreted 50 μm away, raising the question of how long-distance Wg spreading occurs. In this issue of JCB, Wang and Page-McCaw (2014. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201403084) demonstrate a potential mechanism by which the heparan sulfate proteoglycan Dally-like (Dlp) promotes Wg travel, whereas matrix Mmp2 (Metalloproteinase 2) impedes it by inactivating Dlp.

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Droujinine, I. A., Yan, D., & Perrimon, N. (2014). A sharp end to sugary wingless travels. Journal of Cell Biology. Rockefeller University Press. https://doi.org/10.1083/jcb.201408115

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