1. Adenine administered either parenterally or orally is less toxic to the pig than to other species; doses of 100 mg/kg are rapidly catabolised and excreted largely as soluble purine end-products in the urine. 2. The low toxicity is explained by the excretion of less than 1% of the dose as 2,8-dihydroxyadenine. 3. These results suggest that adenine dosages which give rise to kidney damage must be above a threshold-like level which varies in the different mammalian species, and is higher in the pig than in the rat, dog, rabbit or man.
CITATION STYLE
Cameron, J. S., Simmonds, H. A., Cadenhead, A., & Farebrother, D. (1977). Metabolism of intravenous adenine in the pig. Advances in Experimental Medicine and Biology, 76 A, 196–205. https://doi.org/10.1007/978-1-4613-4223-6_25
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