Signalling and pharmacological properties of the P2Y 14 receptor

Abstract

The P2Y 14 receptor is a relatively broadly expressed G protein-coupled receptor that is prominently associated with immune and inflammatory cells as well as with many epithelia. This receptor historically was thought to be activated selectively by UDP-glucose and other UDP-sugars. However, UDP is also a very potent agonist of this receptor, and may prove to be one of its most important cognate activators. © 2010 Scandinavian Physiological Society.