2,3-(HO)2C6H3OMe (10 g.) and 200 g. PbO2 in 3 l. C6H6 are shaken 10-20 min., and the filtrate is treated with 6 g. o-C6H4(NH2)2 in 80 ml. AcOH and 200 ml. C6H6 and allowed to stand 1.5 hr. at room temp., giving 33% of 1-methoxyphenazine; heated with 55% HBr for 5 hrs. at 110-20°, it yields 70% 1-hydroxyphenazine, which reacts with Me2SO4 to give 58% pyocyanine. [on SciFinder(R)]
CITATION STYLE
Caltrider, P. G. (1967). Pyocyanine. In Antibiotics (pp. 117–121). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-662-38439-8_7
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