Coordinate functional regulation between microsomal prostaglandin e synthase-1 (mPGES-1) and peroxisome proliferator-activated receptor γ (PPARγ) in the conversion of white-to-brown adipocytes

Abstract

Background: Microsomal prostaglandin E (PGE) synthase-1 (mPGES-1) is an inducible enzyme with unknown properties in adipose homeostasis. Results: mPGES-1 is necessary for pre-adipocyte differentiation into beige/brite adipocytes through functional interaction with peroxisome proliferator-activated receptor γ (PPARγ). Conclusion: A coordinate interaction between mPGES-1 and PPARγ is required for white-to-brown fat conversion. Significance: Increases in the number of beige cells in fat exerts beneficial metabolic actions. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.