Several recent studies have found a conserved microRNA (miRNA) family, the miR-34s, to be direct transcriptional targets of p53. miR-34 activation can recapitulate elements of p53 activity, including induction of cell-cycle arrest and promotion of apoptosis, and loss of miR-34 can impair p53-mediated cell death. These data reinforce the growing awareness that non-coding RNAs are key players in tumour development by placing miRNAs in a central role in a well-known tumour-suppressor network. © 2007 Nature Publishing Group.
CITATION STYLE
He, L., He, X., Lowe, S. W., & Hannon, G. J. (2007, November). microRNAs join the p53 network - Another piece in the tumour-suppression puzzle. Nature Reviews Cancer. https://doi.org/10.1038/nrc2232
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