Effect of Cancer Treatments on Testicular Function

Abstract

An increasing proportion of young male cancer patients are cured, why the issue of quality of life (QoL) of survivors plays an important role. Several studies have shown that, among young subjects treated for malignant disease, well preserved reproductive function represents one of the most important aspects of the QoL. In this chapter, the current evidence as well as gabs of knowledge regarding the impact of cancer and cancer treatment on testicular function – including fertility, androgen production and health of the offspring – are summarized. Also recommendations for preservation of fertility prior to cancer therapy as well as clinical management of reproductive issues in male cancer survivors, are given.