Suppressive effect of nitrous oxide on motor evoked potentials can be reversed by train stimulation in rabbits under ketamine/fentanyl anaesthesia, but not with additional propofol

Abstract

The effect of nitrous oxide on myogenic motor evoked potentials (MEPs) after multipulse stimulation is controversial. We investigated the effects of propofol in this paradigm. MEPs were elicited electrically by a single pulse and by trains of three and five pulses in rabbits anaesthetized with ketamine and fentanyl. Nitrous oxide 30-70% was given and MEPs were recorded. After washout of nitrous oxide, propofol was given as a bolus of 10 mg kg-1 followed by 0.8 (n=9) or 1.6 mg kg-1 min-1 (n=8) as a continuous infusion. Nitrous oxide was then readministered and MEPs were recorded. Without propofol, nitrous oxide significantly reduced the amplitude of MEPs dose-dependently, but this effect was reversed by multipulse stimulation. Administration of low-dose propofol enhanced nitrous oxide-induced suppression, and this effect was reversed by five-pulse stimulation. However, high-dose propofol produced a greater increase in suppression, such that even five-pulse stimulation did not overcome the suppression. The results suggest that the degree of reversal of nitrous oxide-induced MEP suppression produced by multipulse stimulation is affected by the administration of propofol.