Resistance of ß-lactam antibiotics in Latin American countries

Abstract

From the observation of antimicrobial activity at the end of the 19th century and the large-scale production of antibiotics in the 1940s, microorganisms have developed multiple mechanisms of resistance to these compounds, due to their indiscriminate use and the passage of the years. All of this makes it difficult to treat infectious diseases. This is the case of several species of gram-positive and gram-negative bacteria, which have decreased their sensitivity to ß-lactam antibiotics as a result of inappropriate use and abuse of their administration. That is why bacterial resistance to these drugs represents a public health problem that is increasing in Latin America, as a result of the emergence of strains resistant to several of these compounds. Against this background, Since there are few systematic analyzes that have been carried out on this subject, this bibliographic review aims to summarize and analyze the scientific publications on resistance to ß-lactam antibiotics in some Latin American countries. For this, publications made in the last five years and indexed in the PubMed, SciELO and LILACS-BIREME databases were studied. The results of the analysis indicate that the identification of resistance genes for ß-lactam antibiotics in the environment is common, especially in the soil and in animal farms; and more than 40% of the strains isolated from clinical samples present some mechanism of resistance to this family of antibiotics. This bibliographic review aims to summarize and analyze the scientific publications on resistance to ß-lactam antibiotics in some Latin American countries. For this, publications made in the last five years and indexed in the PubMed, SciELO and LILACS-BIREME databases were studied. The results of the analysis indicate that the identification of resistance genes for ß-lactam antibiotics in the environment is common, especially in the soil and in animal farms; and more than 40% of the strains isolated from clinical samples present some mechanism of resistance to this family of antibiotics. This bibliographic review aims to summarize and analyze the scientific publications on resistance to ß-lactam antibiotics in some Latin American countries. For this, publications made in the last five years and indexed in the PubMed, SciELO and LILACS-BIREME databases were studied. The results of the analysis indicate that the identification of resistance genes for ß-lactam antibiotics in the environment is common, especially in the soil and in animal farms; and more than 40% of the strains isolated from clinical samples present some mechanism of resistance to this family of antibiotics. For this, publications made in the last five years and indexed in the PubMed, SciELO and LILACS-BIREME databases were studied. The results of the analysis indicate that the identification of resistance genes for ß-lactam antibiotics in the environment is common, especially in the soil and in animal farms; and more than 40% of the strains isolated from clinical samples present some mechanism of resistance to this family of antibiotics. For this, publications made in the last five years and indexed in the PubMed, SciELO and LILACS-BIREME databases were studied. The results of the analysis indicate that the identification of resistance genes for ß-lactam antibiotics in the environment is common, especially in the soil and in animal farms; and more than 40% of the strains isolated from clinical samples present some mechanism of resistance to this family of antibiotics.