Background: Prolonged psychosocial stress is a condition assessed through self-reports. Here we aimed to identify biochemical markers for screening and early intervention in women. Methods: Plasma concentrations of interleukin (IL) 1-α, IL1-β, IL-2, IL-4, IL-6, IL-8, IL-10, interferon-γ (INF-γ), tumor necrosis factor-α (TNF-γ), monocyte chemotactic protein-1 (MCP-1), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), thyroid stimulating hormone (TSH), total tri-iodothyronine (TT3), total thyroxine (TT4), prolactin, and testosterone were measured in: 195 women on long-term sick-leave for a stress-related affective disorder, 45 women at risk for professional burnout, and 84 healthy women. Results: We found significantly increased levels of MCP-1, VEGF and EGF in women exposed to prolonged psychosocial stress. Statistical analysis indicates that they independently associate with a significant risk for being classified as ill. Conclusions: MCP-1, EGF, and VEGF are potential markers for screening and early intervention in women under prolonged psychosocial stress. © 2009 Åsberg et al.
CITATION STYLE
Åsberg, M., Nygren, Å., Leopardi, R., Rylander, G., Peterson, U., Wilczek, L., … Ekman, R. (2009). Novel biochemical markers of psychosocial stress in women. PLoS ONE, 4(1). https://doi.org/10.1371/journal.pone.0003590
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