Conclusions and future studies

Abstract

Individuals with LS and GHR-/- mice allow for an interesting comparison between a human genetic condition and genetically manipulated mice. Clearly, much caution has to be used in direct comparison not only because of species differences but also as various factors including age, gender, and other environmental influences (such as pharmaceutical management and diet) can alter the findings. Importantly, the similarities and differences can provide insight into important biological processes in a growth hormone-resistant state. For example, the increased longevity in GHR-/- mice, but not as yet determined in Laron individuals, could provide useful information about aging. Further, the more thorough understanding of the similarities and differences between LS and GHR-/- may aid in the treatment and in the understanding of the physiological and molecular basis of LS individuals. Finally, a compilation of the data in this book from a selected set of LS patients in combination with data from the GHR-/- mouse provides a valuable reference resource. © Springer-Verlag Berlin Heidelberg 2011.