Abstract
Leishmanicidal activity of the 3-(3,4,5-trimethoxyphenyl) propanoic acid (TMPP) isolated from EtOH extracts of the Amazonian Piper turbeculatum Jacq. fruits was evaluated in vitro using Leishmania amazonensis promastigotes. The TMPP was assayed at concentrations of 1600 to 6.25 μg/mL for 24, 48, 72 and 96 h. Promastigotes viability was analyzed and the IC50 of TMPP was 145 μg/mL.
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Ferreira, M. G. P. R., Kayano, A. M., Silva-Jardim, I., da Silva, T. O., Zuliani, J. P., Facundo, V. A., … Stábeli, R. G. (2010). Antileishmanial activity of 3-(3,4,5-trimethoxyphenyl) propanoic acid purified from Amazonian Piper tuberculatum Jacq., Piperaceae, fruits. Revista Brasileira de Farmacognosia, 20(6), 1003–1006. https://doi.org/10.1590/S0102-695X2010005000033
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