Preparation of histone deacetylase inhibitor vorinostat-loaded poly D, L-lactide-co-glycolide polymeric nanoparticles by nanoprecipitation method

Abstract

Nanotechnology is a comparatively new branch of science that includes harnessing the unique properties of particles that are nanometers in scale. Nanoparticles can be tailored in a precise fashion where their size, composition, and surface chemistry can be carefully controlled. The nanoprecipitation is a simple, powerful, and low-energy requiring technique, commonly used for the preparation of defined nanoparticles. Histone deacetylase inhibitor Vorinostat-loaded Poly D, L -lactide-co-glycolide (PLGA) polymeric nanoparticles were prepared by the nanoprecipitation technique. The technique commonly relies on the precipitation of a solvent-dissolved material as nanosize particles after the addition to a non-solvent-containing stabilizer. The particle size and size distribution of the Vorinostat polymeric nanoparticles are significantly influenced by the surfactants used in the fabrication process of the formulation. The surfactants prevent aggregate formation and improve the stability of the nanoparticles. The partitioning and evaporation of organic solvents allowed the formation of Vorinostat-loaded polymeric nanoparticles.