Does Helicobater pylori initiate or perpetuate immune thrombocytopenic purpura?

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Abstract

To determine the prevalence of Helicobacter pylori (H pylori) infection in North American patients with immune thrombocytopenic purpura (ITP) and the effect of H pylori eradication on the platelet count, a prospective study was performed. Seventy-four patients aged 10 years and older (mean age of 41 years) with chronic ITP and a platelet count below 60 × 109/L were enrolled. Hpylori infection was found in 22% of patients by means of a breath test and could not be predicted by gastrointestinal symptoms. H pylori-positive patients (52.5 years of age) were older than H pylori-negative patients (38.5 years of age; P = .0035). Fifteen of the 16 H pylori-positive patients were treated and the bacteria was eradicated in 14 (93%). After 3 months, a significant response (platelet count > 50 × 109/L and doubling the initial count) was observed in only one patient. After a median follow-up of 11.5 months, none of the 14 patients had responded. Ten H pylori-negative patients treated with the same regimen also did not increase their platelet counts. In conclusion, unlike several previous reports, this study does not implicate H pylori in the pathogenesis of ITP since the prevalence of H pylori infection was low and eradication of H pylori did not positively influence the course of the ITP. © 2004 by The American Society of Hematology.

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CITATION STYLE

APA

Michel, M., Cooper, N., Jean, C., Frissora, C., & Bussel, J. B. (2004). Does Helicobater pylori initiate or perpetuate immune thrombocytopenic purpura? Blood, 103(3), 890–896. https://doi.org/10.1182/blood-2003-03-0900

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