The purpose of this work was to explore the potential application of MCNT as a colon-specific delivery system based on the enzyme responsive mechanism. A novel type of enzyme-sensitive colon-specific tablet (PM-tablet) based on pectin and multi-walled carbon nanotube (MCNT) was prepared by wet granulation tabletting method. The PM-tablet in the presence of pectinase exhibited enzyme degradation release and achieve a precise release in the colon. Our study had proposed a novel idea for the application of MCNT on the oral colon-specific drug delivery system.
CITATION STYLE
Zhu, W., Han, C., Dong, Y., & Jian, B. (2019). Enzyme-responsive mechanism based on multi-walled carbon nanotubes and pectin complex tablets for oral colon-specific drug delivery system. Journal of Radioanalytical and Nuclear Chemistry, 320(2), 503–512. https://doi.org/10.1007/s10967-019-06501-0
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