ncRNADrug:ã database for validatedãnd predicted ncRNAsãssociated with drug resistanceãnd targeted by drugs

Abstract

Drug resistance isã major barrier in cancer treatmentãndãnticancer drug de v elopment. Gro wing e vidence indicates that non-coding RNAs (ncR- NA s), especially microRNA s (miRNA s), long non-coding RNA s (lncRNA s)ãnd circular RNA s (circRNA s), pla y piv otal roles in cancer progression, therapy,ãnd drug resistance. Furthermore, ncRNAs ha v e been pro v en to be promising no v el therapeutic targets f or cancer treatment. R e v ers- ing dysregulated ncRNAs by drugs holds significant potentialãsãn effective therapeutic strategy for overcoming drug resistance. Therefore, w e de v eloped ncRNADrug,ãn integratedãnd comprehensive resource that records manually curatedãnd computationally predicted ncRNAsãssociated with drug resistance, ncRNAs targeted by drugs,ãs wellãs potential drug combinations for the treatment of resistant cancer. Cur- rently, ncRNADrug collects 29 551 experimentally validated entries involving 9195 ncRNAs (2248 miRNAs, 4145 lncRNAsãnd 2802 circRNAs)ãssociated with the drug resistance of 266 drugs,ãnd 32 969 entries in v olving 10 480 ncRNAs (4338 miRNAs, 6087 lncRNAsãnd 55 circRNAs) targeted by 965 drugs. Inãddition, ncRNADrugãlso containsãssociations between ncRNAsãnd drugs predicted from ncRNA expression profiles by differential expressionãnalysis. Altogether, ncRNADrug surpasses the existing related databases in both data volumeãnd functionality. It will beã useful resource for drug developmentãnd cancer treatment. ncRNADrug isãvailableãt http:// www.jianglab.cn/ ncRNADrug .