Stereocontrolled total synthesis of (-)-aurisides A and B

Abstract

An expedient total synthesis of aurisides A and B (1), unusual cytotoxic macrolide glycosides isolated from the Japanese sea hare D. auricularia, takes advantage of a highly convergent aldol-based route for the stereocontrolled construction of the common macrolide core. This is followed by α-selective glycosylation to introduce the sugar moieties. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.