The generation of genetically modified alleles in mice using conventional transgenesis technologies is a long and inefficient process. A new study shows that the in situ delivery of CRISPR/Cas9 reagents into pregnant mice results in a high efficiency of editing, and enables the rapid generation of both simple and complex alleles.
CITATION STYLE
Burgio, G. (2018). Redefining mouse transgenesis with CRISPR/Cas9 genome editing technology. Genome Biology, 19(1). https://doi.org/10.1186/s13059-018-1409-1
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