Synthesis and pharmacological profile of a new selective G protein-coupled receptor 119 agonist; 6-((2-Fluoro-3-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl) piperidin-4-yl)propyl)amino)-2,3-dihydro-1H-inden-1-one

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Abstract

6-((2-Fluoro-3-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperid-in-4-yl)propyl) amino)-2,3-dihydro-1 H -inden-1-one is a potent drug-like G protein-coupled receptor 119 (GPR119) agonist. It is hoped that this compound would be instrumental in probing the pharmacological potential of GPR119 agonists. © 2012 The Pharmaceutical Society of Japan.

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Sakairi, M., Kogami, M., Torii, M., Makino, M., Kataoka, D., Okamoto, R., … Watanabe, N. (2012). Synthesis and pharmacological profile of a new selective G protein-coupled receptor 119 agonist; 6-((2-Fluoro-3-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl) piperidin-4-yl)propyl)amino)-2,3-dihydro-1H-inden-1-one. Chemical and Pharmaceutical Bulletin, 60(9), 1093–1095. https://doi.org/10.1248/cpb.c12-00484

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