Selling the Cloud to Smaller Business Organisations

Abstract

Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes of mixed drug Paracetamol (HL) and Sulfamethoxazole (HL 1) were synthesized and characterized by room temperature magnetic moments, melting points, percentage metal, conductance measurements, infrared and electronic spectroscopies. The percentage metal analysis showed that the complexes mostly analyzed as [M(HL)(HL 1)X2].nH2O, X = Cl or NO3, and [M(HL)(HL 1)(SO4)].nH2O. Infrared spectra data confirmed that coordination was through phenol and carbonyl oxygen atoms of Paracetamol, while the coordination in Sulfamethoxazole was through the nitrogen and oxygen atoms of the amine and sulphone groups. The room temperature magnetic moment and electronic spectra data indicated that all the metal(II) complexes were monomeric and octahedral, with the exception of the Cu(II) complex which was dimeric and antiferromagnetic. Furthermore, the Fe(II) complex exhibited high spin low spin octahedral equilibrium. The molar conductance measurements of the metal(II) complexes in DMSO confirm that the complexes were all covalent, with the exception of the Ni(II) complex which was a 1:1 electrolyte. Interestingly, the in-vitro antimicrobial studies on these mixed drug metal(II) complexes, Paracetamol and Sulfamethoxazole against Escherichia spp, Streptococcus spp, Proteus sp, Candida albicans, Salmonella sp, Bacillus spp, Staphylococcus sp, and Pseudomonas spp showed that [Co(HL)(HL 1)Cl2].2H2O, [Cu(HL)(L 1)(NO3)]2.H2O and [Cu(HL)(HL 1)SO4].H2O have higher inhibitory zones than Streptomycin (2.0-29.0 mm) against these microbes with the exceptions of Escherichia spp, and inhibitory zones range of 19.0-28.0, 17.0-27.0 and 13.0-29.0 mm respectively, proving their potentials as broad-spectrum antimicrobial agents.