Arugomycin, A New Anthracycline Antibiotic I. Taxonomy, Fermentation, Isolation And Physico-Chemical Properties

Abstract

Arugomycin (AGM) is a new anthracycline antibiotic produced by strain No. 1098-AV2 which was identified as Streptomyces violaceochromogenes. AGM was isolated by solvent extraction, silicic acid chromatography and Sephadex LH-20 column chromatography. Acid treatment of AGM gave the chromophore, named arugorol, which was identified as 4’-epi-nogalarol, and sugar moieties. AGM inhibited the growth of Gram-positive bacteria and showed antitumor activity against sarcoma S-180 and Ehrlich ascites tumors. © 1987, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.