The Principles of Tetragonia tetragonoides having Anti-ulcerogenic Activity. II. Isolation and Structure of Cerebrosides

Abstract

Compound B1(tentative name), isolated from Tetragonia tetragonoides as a principle with anti-ulcerogenic activity, was determined to be a mixture of geometrical isomers of 1-O-β-D-glucopyranosyl-2-N-2/-hydroxypalmitoyl-sphinga-4,8-dienine on the basis of chemical and spectral evidence. By repeated chromatography, compound B1was separated into compounds B1_a(major) and B1_b(minor), which were found to be the 4-trans-8-trans and 4-trans-8-cis isomers, respectively. Several cerebrosides and glycolipids from various biological sources were examined for protective activity against the ulcer formation in mice under restraint and water immersion condition. © 1983, The Pharmaceutical Society of Japan. All rights reserved.