Organic synthesis based on cyclodextrins template method

Abstract

The organic synthesis based on cyclodextrin template method is reviewed initially by using the "template" concept. These organic synthesis reactions are divided into two main types: one type is based on cyclodextrin "static" template which includes the primary, secondary faces and the cavity. The reactions based on the primary and secondary faces mainly show that the template can control the stereo-structure. While the reactions based on the cavity are mainly using the size and chiral properties of the cavity to do the chemical, regio- and stereo-selectivity, showing that the template can carry out information transfer. The other type is based on cyclodextrin "dynamic" template including the bridge-linked cyclodextrin dimmers with variable conformations and the assemblies prepared by the cyclodextrin derivatives and inclusion complexes. These dynamic templates themselves can be adjusted. © 2012 Chinese Chemical Society & SIOC, CAS.