The hypolipidemic activity of heterocyclic thiosemicarbazones, thioureas and their metal complexes in Sprague Dawley male rats

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Abstract

Heterocyclic thiosemicarbazones, thioureas and their copper, nickel, and cobalt complexes were shown to be potent hypolipidemic agents in male Sprague Dawley rats at 8 mg/kg/day, orally. These agents lowered the activity of rat hepatic rate limiting enzymes for the synthesis of cholesterol and triglycerides. The effects of these agnets on cytoplasmic ATP-dependent citrate lyase, acetyl CoA synthetase and HMG-CoA reductase activities were reduced by a magnitude to explain the reduction of serum cholesterol levels afforded by the compounds. The reduction of acetyl CoA carboxylase, sn-glycerol-3-phosphate synthetase and phosphotidylate phosphohydrolase activities caused by the derivatives is of sufficient magnitude to explain the observed reduction in serum triglycerides after administration of the agents.

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Hall, I. H., Chen, S. Y., Barnes, B. J., & West, D. X. (1999). The hypolipidemic activity of heterocyclic thiosemicarbazones, thioureas and their metal complexes in Sprague Dawley male rats. Metal-Based Drugs, 6(3), 143–147. https://doi.org/10.1155/MBD.1999.143

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