Extended spatial evolutionary games and induced bystander effect

Abstract

The main goal of the study is modelling of radiation induced bystander effect using evolutionary game theory. A payoff table for three different phenotypes (game-theoretic strategies) contains: costs/profits of bystander effect, choice of apoptotic pathway, producing growth factors and resistance against bystander effect. Games are played on a lattice and for that purpose two kinds of spatial evolutionary games are presented and compared. Moreover different polymorphic equilibrium points dependent on model parameters and cells reproductions are discussed.