Photodynamic therapy (PDT) using the photosensitizer Photofrin is approved for the clinical treatment of solid tumors. PDT causes cytotoxic oxidative stress, but additionally induces prosurvival molecules such as cyclooxygenase-2 (COX-2). Combining PDT with COX-2 inhibitors increases the efficacy of in vivo treatment. Understanding mechanisms leading to prosurvival molecule induction is relevant to the design of more effective treatments. Using COX-2 promoter constructs, transcription factor-binding assays, identification of protein kinase activation, and inhibitors of transcription factor binding we were able to determine that COX-2 expression following PDT involves the p38 MAP kinase pathway. © 2010 Springer Science+Business Media, LLC.
CITATION STYLE
Luna, M., Ferrario, A., Wong, S., & Gomer, C. J. (2010). Identification of MAP kinase pathways involved in COX-2 expression following photofrin photodynamic therapy. Methods in Molecular Biology, 635, 47–63. https://doi.org/10.1007/978-1-60761-697-9_4
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