Real-world outcomes in patients with ALK-positive non-small cell lung cancer treated with crizotinib

Abstract

Background Crizotinib has shown greater efficacy in clinical trials than chemotherapy in patients with anaplastic lymphoma kinase-positive (ALK+) non-small cell lung cancer (NSCLC), but little information is available on its use and outcomes in real-world settings. We therefore assessed treatment patterns and outcomes in ALK+ NSCLC patients treated with crizotinib in regular clinical practice. Methods A retrospective medical record review was conducted in North America for adults with ALK+ NSCLC treated with crizotinib as first- or later-line therapy for metastatic disease between 1 August 2011 and 31 March 2013 (for the United States) or 1 May 2012 and 31 March 2013 (for Canada). Crizotinib-related trial enrollees were excluded. Descriptive analyses were conducted to assess treatment patterns and objective response rate (ORR). Progression-free survival (PFS) and overall survival (OS) were descriptively analyzed using Kaplan-Meier methods. Results Data were extracted for 212 patients in the United States (n = 147) and Canada (n = 65). Mean (standard deviation [SD]) age was 58.9 (9.5) years, and 69% were male. Seventy-nine patients (37%) were deceased at record abstraction. Sixty-five percent (n = 137) initiated crizotinib as first-line therapy. Mean (SD) duration of crizotinib treatment was 8.7 (4.9) months. Objective response rate was 66% (69% for first-line recipients, 60% for second-/laterline). Median (95% CI) PFS and OS from crizotinib initiation were 9.5 (8.7, 10.1) and 23.4 (19.5, -) months, respectively. One- and two-year survival probabilities were 82% and 49%, respectively. Conclusions Outcomes for crizotinib recipients in this study align with previous trials, with ORR appearing more favourable in first-line recipients. Our findings indicate that crizotinib outcomes in clinical studies may translate to regular clinical practice.