Magnetic particle imaging for aerosol-based magnetic targeting

Abstract

Magnetic targeting is a strategy for improving the efficacy of therapeutic agents and minimizing the unwanted side effects by attaching the therapeutic agents to magnetic nanoparticles (MNPs) and concentrating them to the targeted region such as solid tumors and regions of infection using external magnetic fields. This study was undertaken to investigate the usefulness of magnetic particle imaging (MPI) for monitoring the effect of aerosol-based magnetic targeting by phantom experiments using a simple flow model and nebulized MNPs. Our results suggest that MPI is useful for monitoring the effect of aerosol-based magnetic targeting.