Distinct subunit-specific α-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid (AMPA) receptor trafficking mechanisms in cultured cortical and hippocampal neurons in response to oxygen and glucose deprivation

Abstract

Background: Hippocampal CA1 neurons are more vulnerable to global ischemia than cortical neurons. Rapid internalization of GluA2 subunit contributes to OGD-induced hippocampal neuronal death. Results: GluA2 subunit is not internalized in response to OGD in cortical neurons. Conclusion: A crucial aspect of the mechanism leading to cell death is absent in cortical neurons. Significance: Differences in GluA2 trafficking may contribute to neuronal vulnerability to ischemia. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.