The obesity epidemic has forced us to evaluate the role of inflammation in the health complications of obesity. This has led to a convergence of the fields of immunology and nutrient physiology and the understanding that they are inextricably linked. The reframing of obesity as an inflammatory condition has had a wide impact on our conceptualization of obesity-associated diseases. In this Review, we highlight the cellular and molecular mechanisms at play in the generation of obesity-induced inflammation. We also emphasize how defining the immune regulation in metabolic tissues has broadened the understanding of the diversity of inflammatory responses. Copyright © 2011, The American Society for Clinical Investigation.
CITATION STYLE
Lumeng, C. N., & Saltiel, A. R. (2011, June 1). Inflammatory links between obesity and metabolic disease. Journal of Clinical Investigation. https://doi.org/10.1172/JCI57132
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