Efek Hipoglikemik dan Hepatoprotektif Fraksi Air Lingzhi (Ganoderma lucidum) pada Tikus Diabetes Mellitus

Abstract

This study is conducted to observe the hipoglicemic and hepatoprotective effect due to administration of water extract of lingzhi (G. lucidum) to aloxan monohydrate induced diabetic rats. The hepatoprotective effect was evaluated by histopathological view of the liver. Thirty-six rats devided into 6 groups, i.e: control, diabetic, glibenclamid comparing, and treatment group. Rats of the treatment group were administered by the water extract of G. lucidum with the dose of 225 mg/kg.BW. Within the 0 day, rats were intraperitoneal injected by the dose of 150mg/kg.BW. After persistent diabetic effect was appeared, glibenclamid or water fraction of G. lucidum were given 9 days respectively. In day 10, rats were dinecropsed for histopathological observation using haematoxylin/ eosin staining. The result of the study showed that water fraction of G. lucidum succesfully lowering blood-glucose level as well as glibenclamid does. Histopathological picture of liver tissue also reveal that water fraction of G. lucidum could protect liver from damage due to diabetic condition. That was proven by the morphological characteristics of hepatocyte through repair and recovery.