Anticancer Property in Acampe praemorsa and Aerides odorata (Orchidaceae), an In Vitro Approach

Abstract

The present study aims at the in vitro cytotoxic effect of epiphytic orchids, viz., Acampe praemorsa and Aerides odorata. Plants were collected from the Eastern Ghats of the Visakhapatnam district, Andhra Pradesh, India. Leaf materials were shade dried; ethyl acetate and methanolic leaf extracts were prepared for this investigation. The leaf extracts were tested for their inhibitory effect on HeLa and MCF-7 cell lines, which were evaluated by the MTT assay; these plants showed good anticancer activity and did not show any adverse effect to normal cells. Both extracts showed good anticancer activity on the MCF-7 cell line than on the HeLa cell line. The methanolic leaf extract of Aerides odorata has significant cytotoxicity effect on the MCF-7 with concentration ranging from 5 to 100 μg/ml, with an IC 50 (μg/ml) value 26.211. The findings from this study showed that the methanolic extract of the A. odorata leaf possesses vast potential as a medicinal drug in breast cancer treatment.