Sustainability and Chaos in the Abiotic Polymerization of 3′,5′ Cyclic Guanosine Monophosphate: The Role of Aggregation

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Abstract

Polymerization of 3′,5′ cyclic guanosine monophosphate (3′,5′ cGMP) was previously reported to afford short RNA sequences from a plausible mildly activated prebiotic precursor in a non-enzymatic and template-free manner. In the current paper we analyze the reaction with PAGE as well as by infrared micro- and nanospectroscopy on time scales not considered before. We provide evidence that a preliminary oligomerization step in dry state allows for a continued synthesis of RNA oligomers even in the presence of subsequently added water. On a longer time scale, the oligomerization yield oscillates in an apparently chaotic fashion hinting at the importance of some non-reversible phase-separation processes on the experimentally observed outcome of the polymerization/degradation chemistries. The long-lasting (hundreds of hours) intrinsic sustainability and resilience of the process gives a robust prebiotic potential to this unique oligomerization reaction, which could lead to the very first oligonucleotide sequences on the primordial Earth.

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Costanzo, G., Šponer, J. E., Šponer, J., Cirigliano, A., Benedetti, P., Giliberti, V., … Di Mauro, E. (2021). Sustainability and Chaos in the Abiotic Polymerization of 3′,5′ Cyclic Guanosine Monophosphate: The Role of Aggregation. ChemSystemsChem, 3(1). https://doi.org/10.1002/syst.202000011

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