N-tert-Butyl-2-{2-[2-(4-chlorophenyl)-4-hydroxy-1- (5-methylisoxazol-3-yl)-5-oxo-2,5-dihydro-1Hpyrrol- 3-yl]-N-(4-methoxyphenyl)acetamido}-2-(4- methoxyphenyl)acetamide methanol monosolvate: Single-crystal X-ray diffraction study and Hirshfeld surface analysis

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Abstract

The title compound, C36H37ClN4O7·CH3OH, which crystallizes as a methanol solvate, may possess biological activity, which is inherent for a natural peptide or protein. In the crystal, mol ecules of the title compound form hydrogen-bonded tetra mers with the solvate mol ecules acting as bridges as a result of the O - H⋯O and N - H⋯O inter molecular hydrogen bonds. Hirshfeld surface analysis was used to study the different types of inter molecular inter actions whose contributions are: H⋯H = 53.8%, O⋯H/H⋯O = 19.0%, C⋯H/H⋯C = 14.8%, Cl⋯H/H⋯Cl = 5.3%, N⋯H/H⋯N = 3.2%.

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Shyshkina, M. O., Sakhno, Y. I., Radchenko, O. V., Shishkina, S. V., Desenko, S. M., & Chebanov, V. A. (2021). N-tert-Butyl-2-{2-[2-(4-chlorophenyl)-4-hydroxy-1- (5-methylisoxazol-3-yl)-5-oxo-2,5-dihydro-1Hpyrrol- 3-yl]-N-(4-methoxyphenyl)acetamido}-2-(4- methoxyphenyl)acetamide methanol monosolvate: Single-crystal X-ray diffraction study and Hirshfeld surface analysis. Acta Crystallographica Section E: Crystallographic Communications, 77, 1208–1212. https://doi.org/10.1107/S2056989021011312

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