Abnormal bone mineral maturation in the chronic uremic state

Abstract

X ray diffraction analysis of bone from chronically uremic but nonacidotic rats with normocalcemia and hyperphosphatemia revealed smaller apatite crystals and in increase in the X ray amorphous mineral fraction when compared to age matched, pair fed control animals, indicating less advanced mineral maturation in the uremic animals. Studies in animals with varied degrees of chronic renal insufficiency revealed a progression of the bone crystal maturational defect with advancing uremia.