Kidney disease as a determinant of cognitive decline and dementia

47Citations
Citations of this article
80Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Chronic kidney disease (CKD) has evolved as a possible new determinant of cognitive decline and dementia. This review outlines the presumed pathophysiology of cognitive decline in CKD, which consists of traditional and new vascular risk factors as well as nonvascular risk factors and metabolic and biochemical abnormalities within the central nervous system caused by CKD. The recent major cross-sectional studies and longitudinal studies - including one meta-analysis - that mostly suggest an association of cognitive decline and CKD are discussed. Finally, potential therapeutic strategies are presented.

Cite

CITATION STYLE

APA

Etgen, T. (2015). Kidney disease as a determinant of cognitive decline and dementia. Alzheimer’s Research and Therapy. BioMed Central Ltd. https://doi.org/10.1186/s13195-015-0115-4

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free