New neolignan component from camellia amplexicaulis and effects on osteoblast differentiation

Abstract

A new neolignan named "camellioside A" (1) has been isolated from the leaves and branches of Camellia amplexicaulis, along with seven known glycosides (2-8). Their structures were determined by a variety of spectroscopic analyses. Among them, compounds 2, 3, 4, and 6 significantly (p<0.05) increased the alkaline phosphatase activity and the mineralization of the nodules of the MC3T3-E1 osteoblastic cells compared to those of the control. © 2009 Pharmaceutical Society of Japan.