Antagonistic function of the RNA-binding protein HuR and miR-200b in post-transcriptional regulation of vascular endothelial growth factor-a expression and angiogenesis

Abstract

Background: The role of RNA-binding protein HuR in angiogenesis is not known. Results: In macrophages, HuR and miR-200b antagonistically regulate VEGF-A and angiogenesis. Conclusion: Interplay of HuR and miRNAs in the macrophage regulates tumor angiogenesis in the mouse and embryonic vascular development in zebrafish. Significance: HuR modulation of miRNA function highlights the importance of post-transcriptional gene regulatory mechanisms in biology and disease.© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.