The new information generated over the last decade on the physiology/pharmacology of the normal bladder and on the pathophysiology of the overactive bladder has resulted in the introduction of a new therapeutic principle, β3-adrenoceptor (AR) agonism, and the approval of mirabegron, a selective agonist at β3-ARs. It may be asked in what respects the β3-AR agonists as a group, and mirabegron in particular, differ from the antimuscarinics, and what can clinically be gained by the β3-AR agonists. In this short review, the mechanisms of action, clinical efficacy, and adverse effect profiles of the two groups of drugs are compared and discussed. © 2013 Springer Science+Business Media New York.
CITATION STYLE
Andersson, K. E. (2013). β3-receptor agonists for overactive bladder - New frontier or more of the same? Current Urology Reports, 14(5), 435–441. https://doi.org/10.1007/s11934-013-0335-8
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