Erythema multiforme

Abstract

Erythema multiforme (EM) is an acute, immune-mediated dermatological condition affecting the skin and mucous membranes. It develops as a type IV hypersensitivity reaction to infections, medications, or other stimuli. The clinical presentation with target lesions and/or mucosal erosions with a history of exposure to a known trigger is usually sufficient for the diagnosis. Albeit self-limited in most cases, severe or recurrent forms of EM require systemic therapy.