Distinct DNA binding preferences for the c-Myc/Max and Max/Max dimers

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Abstract

The transcription factor c-Myc and its dimerisation partner Max are members of the basic/helix-loophelix/leucine-zipper (bHLH-Z) family and bind to the DNA core sequence CACGTG. Using a site-selection protocol, we determined the complete 12 base pair consensus binding sites of c-Myc/Max (RACCACGTGGTY) and Max/Max (RANCACGTGNTY) dimers. We find that the c-Myc/Max dimer fails to bind the core when it is flanked by a 5′T or a 3′A, while the Max/Max dimer readily binds such sequences. Furthermore we show that inappropriate flanking sequences preclude transactivation by c-Myc in vivo. In conclusion, Max/Max dimers are less discriminatory than c-Myc/Max and may regulate other genes in addition to c-Myc/Max targets. © 1993 Oxford University Press.

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Solomon, D. L. C., Amati, B., & Land, H. (1993). Distinct DNA binding preferences for the c-Myc/Max and Max/Max dimers. Nucleic Acids Research, 21(23), 5372–5376. https://doi.org/10.1093/nar/21.23.5372

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