Crataegus laevigata suppresses lps-induced oxidative stress during inflammatory response in human keratinocytes by regulating the MAPKS/AP-1, nfβb, and NFAT signaling pathways

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Abstract

Crataegus laevigata belongs to the family Rosaceae, which has been widely investigated for pharmacological effects on the circulatory and digestive systems. However, there is limited understanding about its anti-oxidative stress and anti-inflammatory effects on skin. In this study, 70% ethanol C. laevigata berry extract (CLE) was investigated on lipopolysaccharide (LPS)-stimulated keratinocytes. The LPS-induced overproduction of reactive oxygen species (ROS) was suppressed by the treatment with CLE. In response to ROS induction, the overexpression of inflammatory regulating signaling molecules including mitogen-activated protein kinases (MAPK)/activator protein-1 (AP-1), nuclear factor kappa-light-chain-enhancer of activated B cell (NF-βB), and nuclear factor of activated T-cells (NFAT) were reduced in CLE-treated human keratinocytes. Consequently, CLE significantly suppressed the mRNA levels of pro-inflammatory chemokines and interleukins in LPS-stimulated cells. Our results indicated that CLE has protective effects against LPS-induced injury in an in vitro model and is a potential alternative agent for inflammatory treatment.

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Nguyen, Q. T. N., Fang, M., Zhang, M., Do, N. Q., Kim, M., Zheng, S. D., … Yi, T. H. (2021). Crataegus laevigata suppresses lps-induced oxidative stress during inflammatory response in human keratinocytes by regulating the MAPKS/AP-1, nfβb, and NFAT signaling pathways. Molecules, 26(4). https://doi.org/10.3390/molecules26040869

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